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John D. Wilson, M.D.
1200 Hilyard St., Suite S-560
Eugene, Oregon 97401 USA
541/343-6028   fax 485-7702
www.TravelClinicOregon.com

INFLUENZA AND INTERNATIONAL TRAVEL - January 2005

I will try to outline a reasonable benefit/cost/risk analysis of whether to give influenza vaccine to international travelers.

Influenza outbreaks have been documented aboard cruise ships. Air travelers disperse so quickly after landing that it would be impossible to document influenza transmission aboard flights. Influenza is probably passed (like meningococcal disease) by short range droplet as well as person-to-person contact; crowding of people who congregate from multiple geographic sites (increased risk for meningococcal disease in military recruits in barracks, college students in dorms, and travelers to the Hajj). Influenza has a much higher attack rate than meningococcal disease. Fears about ventilation aboard aircraft are probably exaggerated. I am less worried about aircraft ventilation than I am about someone coughing within a few rows of my seat. Maybe also who touched the doorknob I touch just before I scratch my nose, and did he wash his hands after he coughed into them.

The CDC recommends influenza vaccine if a person will be mixing with crowds which may contain international visitors, regardless of the time of year. This would obviously include any air traveler to a destination outside the US. If you think about it, influenza is probably the most vaccine-preventable disease a traveler is likely to contract.

Influenza tends to occur throughout the year (rather than seasonally) the closer one gets to the equator. We already know about influenza occurring in the temperate southern hemisphere during their winter. Each year, I try to have influenza vaccine available for all travelers right up to the June 30 expiration date, and regret not having vaccine available starting July 1. I documented influenza in a traveler returning from Brazil in July, 2002.

I make sure my patients, family, staff and myself are all appropriately immunized against influenza each October, even if we are not traveling, and have been doing so for 25 years.

Domestically, in the US, we have the situation that the vaccine works least well in the patients who need it most (infants and the elderly and the chronically ill), and until we can also immunize the people around them, we will likely continue to have an estimated 30,000 deaths and millions of cases each winter. Unfortunately, we have a media-driven feast/famine guessing game every winter. Federal support for a partial buy-back of unopened vials, operated through the manufacturers, would tend to insure that we will not be reluctant to purchase enough vaccine to meet the needs of our practices. After all, this IS a public health problem.

I believe that, once production and supply problems are worked out, influenza vaccine could reasonably be offered to each person in the US over age 6 months. I am hopeful that a recombinant DNA technology will be found which will make manufacture more reliable, and more responsive to changes in emerging new strains of influenza virus.

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